Genestra TAD+ -120 Tablets
• Multivitamin, mineral, botanical and glandular formulation in tablets • Helps in wound healing and tissue formation, helps to maintain immune function and helps the body to metabolize carbohydrates, fats and proteins
TAD+ provides synergistic vitamins and herbs along with bovine adrenal powder. TAD+ is indicated to help in tissue formation, help maintain immune function, help in wound healing and to help the body metabolize carbohydrates, fats and proteins (1).
References: 1 NHPD Monograph on Multi-Vitamin and Mineral. October 2007.
Additional product info: Over the last several decades, vitamin A has been used in the treatment of various skin disorders. An investigation was conducted to determine whether vitamin A (retinyl palmitate) supplementation at 25,000, 50,000, or 75,000 IU against a placebo significantly increases circulating RA concentrations of all-trans-, 9-cis-, and 13-cis-RA. The results of the study suggests that supplementation with retinyl palmitate is an effective means to increase circulating all-trans, 9-cis-, and 13-cis-RA concentrations among humans (2). The relationship between the concentrations of micronutrients in the plasma and in the target tissues has not been established. To gain information on tissue micronutrient concentration and its relationship to the plasma level, paired skin and plasma samples from 93 patients with actinic keratoses were obtained (3). Another study showed that retinol palmitate at 10,000 IU by mouth for 90 days significantly reduced rectal symptoms of radiation proctopathy, perhaps because of wound-healing effects (4).
Corneal haze and myopic regression are the main undesirable complications after excimer laser treatment. In the past few years, several authors indicated that keratocytes and epithelial cells are mainly involved in the healing response. In particular, it was suggested that the disappearance of anterior stromal keratocytes in response to excimer laser surgery was an initiating factor, which could lead to epithelial hyperplasia and eventually to haze formation and regression. Vitamin A exerts a moderate antioxidant activity and plays an essential part in epithelial growth and limbal stem cell differentiation, promoting corneal wound healing. As slower tissue regeneration causes an increased risk of accumulation of oxidant inflicted damage in the tissue components, corneal re-epithelialisation time is crucial. A randomized, double masked clinical trial has been performed to evaluate the effect of a high dose vitamin A and E supplementation on corneal re-epithelialisation time, visual acuity and haze following photorefractive keratectomy (PRK). In this study, the results showed that vitamins A (25 000 IU retinol palmitate) and E (230 mg alpha-tocopheryl nicotinate) for 3 months post PRK significantly decreased re-epithelialisation time, haze formation, and myopic regression occurrence (5).
Bone matrix contains over 90% of protein as collagen and it is well established that vitamin C is an essential cofactor for collagen formation and synthesis of hydroxyproline and hydroxylysine required for the formation of stable triple helixes. Furthermore, animal studies have demonstrated that experimental deficiency of vitamin C leads to impaired bone mass, cartilage, and connective tissue. Several epidemiologic studies have examined the association of vitamin C in relation to bone mineral density (BMD). A study evaluated the associations of total, supplemental, and dietary vitamin C intake with bone mineral density (BMD) at the hip [femoral neck, trochanter], spine, and radial shaft and 4-y BMD change in elderly participants from the Framingham Osteoporosis Study. Among 334 men and 540 women, the authors observed an unexpected negative cross-sectional association of total vitamin C and supplemental vitamin C intake with trochanter BMD among men who were current smokers. In contrast, dietary vitamin C appeared to be protective against 4-y losses in BMD among men, whereas total vitamin C appeared to be protective only among men with low calcium or vitamin E intakes. These results suggest a possible protective role of vitamin C for bone health in older men (6). Daily vitamin C supplement intake ranging from 100 to 5,000 mg appears to have a beneficial effect on levels of BMD, especially among postmenopausal women using concurrent estrogen therapy and calcium supplements (7).
Adequate zinc status is critical for immune function. Zinc deficiency reduces generation of T cells, depresses humoral and cell-mediated immunity, leads to lymphopenia and thymic atrophy, and increases the frequency and number of infections (8). A prospective, randomized, controlled clinical trial was conducted involving 231 HIV-infected adults with low plasma zinc levels, who were randomly assigned to receive zinc (12 mg of elemental zinc for women and 15 mg for men) or placebo for 18 months. Zinc supplementation given to HIV-infected adults resulted in a 4-fold decrease in the likelihood of immunological failure, defined as a decrease of CD4+ cell count to <200 cells/mm3, after 18 months of use, compared with placebo. Zinc supplementation also significantly reduced diarrhea, compared with placebo (9). Zinc aspartate is source material of zinc in Genestra Brands TM TAD+. In a clinical trial, 300 mg of zinc aspartate (equal to 60 mg elemental zinc per day) was administered to 14 patients with inactive to moderately active inflammatory bowel disease for 4 weeks in order to evaluate the effect of oral zinc supplementation on metallothionein and superoxide dismutase levels in these patients. The plasma zinc concentration of these patients was significantly lower at the start of the study when compared to that of 22 healthy controls, but increased significantly towards the levels of controls during the supplementation period (10).
Licorice (root and flowers) at 600-15,000 mg per day is used in Herbal Medicine to help relieve inflammatory conditions of the gastrointestinal tract, such as gastritis in adults (11). Attributes of TAD+ covered by the NHPD Monographs: Helps the body to metabolize carbohydrates, fats and proteins. Helps normal growth and development. Helps in tissue formation. Helps to maintain eyesight, skin, membranes and immune function. Helps in the development and maintenance of night vision. Helps in the development and maintenance of bones, cartilage, teeth and gums. Helps in wound healing. An antioxidant for the maintenance of good health. Helps to prevent niacin, pantothenic acid, riboflavin, thiamine, vitamin A, vitamin B6, vitamin C and zinc deficiency.
References: 2 Sedjo RL, Ranger-Moore J, Foote J, Craft NE, Alberts DS, Xu MJ, Giuliano AR. Circulating endogenous retinoic acid concentrations among participants enrolled in a randomized placebo-controlled clinical trial of retinyl palmitate. Cancer Epidemiol Biomarkers Prev. 2004 Nov;13(11 Pt 1):1687-92. Abstract; Page 1687, Introduction, 1st & 2nd paragraphs; Page 1691, Conclusion 3 Peng YM, Peng YS, Lin Y, Moon T, Baier M. Micronutrient concentrations in paired skin and plasma of patients with actinic keratoses: effect of prolonged retinol supplementation. Cancer Epidemiol Biomarkers Prev. 1993 Mar-Apr;2(2):145-50. Abstract; Page 145, Introduction, 2nd paragraph; Page 150, Conclusion 4 Ehrenpreis ED, Jani A, Levitsky J, Ahn J, Hong J. A prospective, randomized, double-blind, placebo-controlled trial of retinol palmitate (vitamin A) for symptomatic chronic radiation proctopathy. Dis Colon Rectum. 2005 Jan;48(1):1-8. Abstract 5 Vetrugno M, Maino A, Cardia G, Quaranta GM, Cardia L. A randomised, double masked, clinical trial of high dose vitamin A and vitamin E supplementation after photorefractive keratectomy. Br J Ophthalmol. 2001 May;85(5):537-9. Abstract; Page 537, Introduction, 1st paragraph; Page 538, Discussion, 1st paragraph; Page 538, 1st paragraph; Page 539, Conclusion 6 Sahni S, Hannan MT, Gagnon D, Blumberg J, Cupples LA, Kiel DP, Tucker KL. High vitamin C intake is associated with lower 4-year bone loss in elderly men. J Nutr. 2008 Oct;138(10):1931-8. 7 Morton DJ, Barrett-Connor EL, Schneider DL. Vitamin C supplement use and bone mineral density in postmenopausal women. J Bone Miner Res. 2001 Jan;16(1):135-40. Abstract (Article to be obtained) 8 Baum MK, Lai S, Sales S, Page JB, Campa A. Randomized, controlled clinical trial of zinc supplementation to prevent immunological failure in HIV-infected adults. Clin Infect Dis. 2010 Jun 15;50(12):1653-60. Abstract; Page 1653, 1st paragraph;Page 1657, Discussion, 1st paragraph; Page 1658, Conclusion 9 Baum MK, Lai S, Sales S, Page JB, Campa A. Randomized, controlled clinical trial of zinc supplementation to prevent immunological failure in HIV-infected adults. Clin Infect Dis. 2010 Jun 15;50(12):1653-60. Abstract; Page 1653, 1st paragraph;Page 1657, Discussion, 1st paragraph; Page 1658, Conclusion 10 Mulder TP, van der Sluys Veer A, Verspaget HW, Griffioen G, Peña AS, Janssens AR, Lamers CB. Effect of oral zinc supplementation on metallothionein and superoxide dismutase concentrations in patients with inflammatory bowel disease. J Gastroenterol Hepatol. 1994 Sep-Oct;9(5):472-7. Abstract 11 NHPD Monograph on Licorice. February 2008.
Other ingredients: calcium hydrogen phosphate dihydrate, cellulose, croscarmellose sodium, magnesium stearate, silica, pharmaceutical glaze