Genestra HMF Cystgen- 6 sachets
• Moderate level probiotic • 10 Billion CFU per dose • With added cranberry • To help prevent Urinary Tract Infections (UTI’s) and to provide antioxidants for the maintenance of good health (1) • Convenient sachet format • Increase patient compliance
HMF Cystgen provides two strains of Lactobacillus formulated for the support and maintenance of a healthy gut microflora. Cranberry, which is approved by Health Canada for its traditional use in Herbal Medicine to help prevent urinary tract infections (UTIs) and to provide antioxidants for the maintenance of good health is added to HMF Cystgen along with potassium citrate, potassium carbonate and vitamin C.
Pharmax and GENESTRA BRANDS™ are probiotic science and innovation leaders, with over 20+ years of proven experience and an ongoing commitment to incorporate the safest and most effective strains that reflect the latest evidence-based research from human trials. Our probiotics are human-sourced strains, proven in human clinical trials and cover a comprehensive product range.
References: 1 NHPD Monograph on Cranberry. March 2011.
Additional product info: The microbial species that inhabit the vaginal tract play an important role in the maintenance of health, and prevention of infection. Despite the close proximity of the vagina to the anus, the diversity of microbes present in the vagina is much lower than in the gut(1) . Urogenital infections not caused by sexual transmission, namely yeast vaginitis, bacterial vaginosis, and urinary tract infection remain a major medical problem in terms of the number of women afflicted each year. Although antimicrobial therapy is generally effective at eradicating these infections, there is still a high incidence of recurrence. The patient’s quality of life is affected and many women become frustrated by the cycle of repeated antimicrobial agents whose effectiveness is diminishing due to increasing development of microbial resistance. There is good clinical evidence to show that the intestinal and urogenital microbial flora have a central role in maintaining both the health and well-being of humans (2) . Oral administration of probiotic strains such as Lactobacillus rhamnosus and Lactobacillus fermentum (3,4) , , or Lactobacillus acidophilus by oral (5) and topical administration (6) , to replace or augment bacterial populations is gradually achieving scientific acceptance (7) . The probiotic organisms present in Genestra Brands™ HMF Cystgen are present in the product formulation to help normalize and restore a healthy gut and vaginal microflora.
Cranberry preparations at 400 mg per day have long been used in traditional herbal medicine to help prevent recurrent urinary tract infections, as a source of antioxidants for the maintenance of good health (8) . Potassium citrate and potassium bicarbonate are included in Genestra Brands™ HMF Cystgen due to their wide-spread use as urinary alkalinizing agents. Past studies have shown that oral potassium citrate (Polycitra K at 2 mEq/Kg per day) effectively increases urinary pH, increases urinary citrate, and decreases incidence of kidney stones in children (9) . Oral potassium bicarbonate (KHCO3 at 30, 60 or 90 mmol/day for 36 months) have been used for treatment of metabolic acidosis and for reducing renal acid production with much success, with additional potential benefits on reducing urine calcium excretion, which is common in individuals with hypertension, calcium urolithiasis and post-menopausal women (10) . Several human clinical trials have evaluated the effect of potassium supplementation, such as potassium citrate at 30 mmol K-cit/day for 6 weeks (11) , 96 mmol/day for 1 week (12) , potassium bicarbonate at 64 mmol/ day for 4 weeks (13) , or 40 mmol daily of potassium chloride for 16 weeks (14) on lowering blood pressure in both normotensive and hypertensive populations, and results from several meta-analysis of randomized clinical trials evaluating potassium supplementation identify beneficial effects on blood pressure through increases in potassium intake (15,16) , , as elevated blood pressure is an important risk factor for cardiovascular mortality and high blood pressure is increasingly prevalent in the general population (17) .
References: 1 Cribby S, Taylor M, Reid G. Vaginal microbiota and the use of probiotics. Interdiscip Perspect Infect Dis. 2008;2008:256490. 2 Reid G, Bruce AW. Urogenital infections in women: can probiotics help? Postgrad Med J. 2003 Aug;79(934):428-32. 3 Reid G, Charbonneau D, Erb J, Kochanowski B, Beuerman D, Poehner R, Bruce AW. Oral use of Lactobacillus rhamnosus GR-1 and L. fermentum RC-14 significantly alters vaginal flora: randomized, placebo-controlled trial in 64 healthy women. FEMS Immunol Med Microbiol. 2003 Mar 20;35(2):131-4. 4 Reid G, Beuerman D, Heinemann C, Bruce AW. Probiotic Lactobacillus dose required to restore and maintain a normal vaginal flora. FEMS Immunol Med Microbiol. 2001 Dec;32(1):37-41. 5 Shalev E, Battino S, Weiner E, Colodner R, Keness Y. Ingestion of yogurt containing Lactobacillus acidophilus compared with pasteurized yogurt as prophylaxis for recurrent candidal vaginitis and bacterial vaginosis. Arch Fam Med. 1996 Nov-Dec;5(10):593-6. 6 Neri A, Sabah G, Samra Z. Bacterial vaginosis in pregnancy treated with yoghurt. Acta Obstet Gynecol Scand. 1993 Jan;72(1):17-9. 7 Reid G, Bruce AW. Urogenital infections in women: can probiotics help? Postgrad Med J. 2003 Aug;79(934):428-32. 8 Stothers L. A randomized trial to evaluate effectiveness and cost effectiveness of naturopathic cranberry products as prophylaxis against urinary tract infection in women. Can J Urol. 2002 Jun;9(3):1558-62. 9 McNally MA, Pyzik PL, Rubenstein JE, Hamdy RF, Kossoff EH. Empiric use of potassium citrate reduces kidney-stone incidence with the ketogenic diet. Pediatrics. 2009 Aug;124(2):e300-4. Epub 2009 Jul 13. 10 Frassetto L, Morris RC Jr, Sebastian A. Long-term persistence of the urine calcium-lowering effect of potassium bicarbonate in postmenopausal women. J Clin Endocrinol Metab. 2005 Feb;90(2):831-4. 11 Braschi A, Naismith DJ. The effect of a dietary supplement of potassium chloride or potassium citrate on blood pressure in predominantly normotensive volunteers. Br J Nutr. 2008 Jun;99(6):1284-92. 12 He FJ, Markandu ND, Coltart R, Barron J, MacGregor GA. Effect of short-term supplementation of potassium chloride and potassium citrate on blood pressure in hypertensives. Hypertension. 2005 Apr;45(4):571-4 13 He FJ, Marciniak M, Carney C, Markandu ND, Anand V, Fraser WD, Dalton RN, Kaski JC, MacGregor GA. Effects of potassium chloride and potassium bicarbonate on endothelial function, cardiovascular risk factors, and bone turnover in mild hypertensives. Hypertension. 2010 Mar;55(3):681-8. 14 Sacks FM, Willett WC, Smith A, Brown LE, Rosner B, Moore TJ. Effect on blood pressure of potassium, calcium, and magnesium in women with low habitual intake. Hypertension. 1998 Jan;31(1):131-8. 15 Geleijnse JM, Kok FJ, Grobbee DE. Blood pressure response to changes in sodium and potassium intake: a metaregression analysis of randomised trials. J Hum Hypertens. 2003 Jul;17(7):471-80. 16 Cappuccio FP, MacGregor GA. Does potassium supplementation lower blood pressure? A meta-analysis of published trials. J Hypertens. 1991 May;9(5):465-73. 17 Braschi A, Naismith DJ. The effect of a dietary supplement of potassium chloride or potassium citrate on blood pressure in predominantly normotensive volunteers. Br J Nutr. 2008 Jun;99(6):1284-92.